Huihua Ji

Huihua Ji

Huihua Ji

Huihua Ji

Principal Investigator, Scientist III

University of Kentucky 1401 University Drive Lexington, KY 40546-0236

Last Revised: Feb 12th, 2024

Professional Biography

Selected Publications

Ji, H.; Jin, Z.; Fenton, L.; Slone, S. (2023) Evaluation of Six Aromatic Amines in the Mainstream Smoke of Commercial Cigars. Chemical Research in Toxicology 2023, 36, 12, 2001–2009

Ji, H., Fenton, L., Slone, S., Guan, S., Wu, Y. (2023) Long-Term Storage Study of the Certified 1R6F Reference Cigarette. Chemical Research in Toxicology 2023, 36, 4, 685–690.

Trotta, R., Harmon, D., Ji, H., Klotz, J. (2023) Duration of ergovaline exposure influences serotonin-mediated vasoactivity of bovine mesenteric vasculature, Journal of Animal Science, Volume 101, 2023, skad100,

Slone, S., McNees, C.R., Craft, M., Ji, H, Shearer, A., Shelton, B., Yuan, L., Chamber, O. (2023) Evaluation of the 1R6F certified reference cigarette for proficiency testing of mainstream smoke parameters. Accred. Qual. Assur. (2023).

Dinkins, D.R., Coe, L.B., Phillips, D.T., Ji, H. (2023) Accumulation of Alkaloids in Different Tall Fescue KY31 Clones Harboring the Common Toxic Epichloë coenophiala Endophyte under Field Conditions.  Agronomy 2023, 13(2), 356;

Davis, B.E, Hamilton, T, A., Johns, J. T., Harmon, D. L., Klotz, J. L., Weinert-Nelson, J. R., Goodman, J. P., May, J., Ji, H., Schrick, F. N., Flythe, M. D. (2022) Conventional loose mineral with added red clover leaf (Trifolium pratense L.) reverses vasoconstriction associated with tall fescue toxicosis in steers. Animal Feed Science and Technology, 2022; Vol. 295 (2023) 115523,

Ji, H., Jin, Z. (2022) Analysis of six aromatic amines in the mainstream smoke of tobacco products. Analytical and Bioanalytical Chemistry, 2022 Apr 11;

Ji, H., Moldoveanu, S. C. (2022). Does the level of NNK in tobacco and tobacco products depend on the level of pseudooxynicotine or of nicotine-1’-N-oxide? Contributions to Tobacco & Nicotine Research, 2022; Vol.31, no.1, pp.25-34. DOI: 10.2478/cttr-2022-0003

Harlow, E.B., Flythe, D.M., Goodman, J.P., Ji, H.,Aiken, G.E. (2022) Isoflavone Containing Legumes Mitigate Ergot Alkaloid-Induced Vasoconstriction in Goats (Capra hircus). Animals 2022, 12, 750.

Harlow, E.B., Flythe, D.M., Hamilton, A.T., Ji, H., Schrick, N., Aiken, E.G. (2021). Effects of overseeding red clover in endophyte-infected tall fescue pastures on steer physiology and performance. Applied Animal Science, 2021; Vol.37(6), p.748-757.  DOI: 10.15232/aas.2021-02152.

Guan, S., Bush, L.P., and Ji, H. (2021). An in vitro study of constituents released from smokeless tobacco products into human saliva. Journal of Analytical Toxicology, 2021; 00:1-8, bkab076;

Kurepa, J., Shull, T. E., Fisher, A., Fisher, C., Ji, H., & Smalle, J. A. (2021). Differential oxidative stress responses and tobacco-specific nitrosamine accumulation in two burley varieties. Journal of Plant Physiology, 261(December 2020), 153429.

Ault-Seay, T.B.; Melchior-Tiffany, E.A.; Clemmons, B.A.; Cordero, J.F.; Bates, G.E.; Flythe, M.D; Klotz, J.L.; Ji, H., Goodman, J.P.; McLean, K.J.; Myer, P.R. (2020). Rumen and serum metabolomes in response to endophyte-infected tall fescue seed and isoflavone supplementation in beef steers. Toxins 2020 12, 744; doi:10.3390/toxins12120744

Ji, H.; Wu, Y.; Fannin, F.; Bush, L. (2019). Determination of tobacco alkaloid enantiomers using reversed phase UPLC/MS/MS. Heliyon 5(5), e01719.

Melchior, E. A., Smith, J. K., Schneider, L. G., Travis Mulliniks, J., Bates, G. E., Flythe, M. D., Klotz, J. L., Ji, H., Goodman, J. P., Lee, A. R., Marc Caldwell, J., & Myer, P. R. (2019). Effects of endophyte-infected tall fescue seed and red clover isoflavones on rumen microbial populations and physiological parameters of beef cattle. Translational Animal Science, Volume 3, Issue 1, January 2019, Pages 315–328.

Melchior, E.; Mulliniks, J.; Smith, J.; Bates, G.; Schneider, L.; Mcfarlane, Z.; Flythe, M.; Klotz, J.; Goodman, J.; Ji, H.; Myer, P. (2018) Effects of red clover isoflavones on tall fescue seed fermentation and microbial populations in vitro. PLoS ONE

Harlow, B.; Goodman, J.; Lynn, B.; Flythe, M.; Ji, H.; Aiken, G. (2017). Ruminal tryptophan-utilizing bacteria degrade ergovaline from tall fescue seed extract. Journal of Animal Science 2017.95:980–988 doi:10.2527/jas2016.1128

Gillman, G.; Ji, H.; Martin, A.; Morton, M. (2017). 2016 Collaborative Study on Minor Alkaloids in Tobacco Products. CORESTA website

Gillman, G.; Ji, H.; Martin, A.; Morton, M. (2017). 2016 Collaborative Study on Nicotine in Tobacco Products. CORESTA website

Cai, B.; Ji, H.; Fannin, F.F. and Bush, L.P. (2016). Contribution of Nicotine and Nornicotine toward the Production of N’‑Nitrosonornicotine in Air-Cured Tobacco (Nicotiana tabacum). J. Nat. Prod. doI: 10.1021/acs.jnatprod.5b00678

Aiken, G.; Flythe, M.; Kagan, I.; Ji, H.; Bush, L.P. (2016). Mitigation of ergot vasoconstriction by clover isoflavones in goats (Capra hircus). Frontiers in Veterinary Science. doi: 10.3389/fvets.2016.00017.

Zheng, Q.; Zheng, Y.; Ji, H.; Burnie, W.; Perry, S. (2016). Gene regulation by the AGL15 transcription factor reveals hormone interactions in somatic embryogenesis.  Plant Physiology 172, pp. 2374-2387

Lu, J.; Zhang, L.; Lewis, R.S.; Bovet, L.; Goepfert, S.; Jack, A.M.; Crutchfield, J.D.; Ji, H.; Dewey, R.E. (2016). Expression of a constitutively active nitrate reductase variant in tobacco reduces tobacco-specific nitrosamine accumulation in cured leaves and cigarette smoke.  Plant Biotechnology Journal 14: 1500-1510 doi: 10.1111/pbi.12510

Bourguignon, M.; Nelson, J. A.; Carlisle, E.; Ji, H.; Dinkins, R. D.; Phillips, T. D.; McCulley, R. L. (2015). Ecophysiological responses of tall fescue genotypes to fungal endophyte infection, elevated temperature, and precipitation. Crop Science doi:10.2135/cropsci2015.01.0020

McCulley, R.L.; Bush, L P.; Carlisle, A.; Ji, H.; Nelson, J. (2014). Warming reduces tall fescue abundance but stimulates toxic alkaloid concentrations in transition zone pastures of the U.S.  Frontiers in Chemistry 2: 88. doi: 10.3389/fchem.2014.00088

Ji, H.; Fannin, F.F.; Klotz, J.; Bush, L.P. (2014). Tall fescue seed extraction and partial purification of ergot alkaloids. Frontiers in Chemistry 2: 110. doi: 10.3389/fchem.2014.00110

Contact Information

1401 University Drive Lexington, KY 40546